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Updated: Sep 19, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Bioactive diterpenoids from the leaves of Callicarpa formosana Rolfe
Panpan Gao1, Yulu Tian1, Haowen Luo1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
Five undescribed clerodane and one labdane diterpenoids (1-6), together with six known diterpenoids (7-12), were isolated from the leaves of Callicarpa formosana Rolfe. Their structures were elucidated by HR-ESI-MS, NMR and ECD spectral data. The bioactivity screening showed (2R,5R,8S,9R,10S)-2-ethoxy-kolavic acid 15-methyl ester (4) displayed anti-inflammatory activity in vivo. In addition, (5S,8S,9R,10S)-kolavic acid (7) and 18-hydroxy-13-methyl-labda-7,13-diene-15-oic acid (12) showed hepatoprotective activity against APAP-induced toxicity in HepG-2 cells.
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