Probiotics and triglyceride manipulation: potential implications for alleviating hypertriglyceridemia

Area of Science:

• Microbiology
• Metabolic Disorders
• Gastroenterology

Background:

• Hypertriglyceridemia is a common lipid disorder, often resulting from genetic and environmental factors.
• Secondary causes include obesity, diabetes, alcohol, diet, and certain medications.
• Gut microbiota modulation via probiotics is a potential strategy to lower triglyceride levels.

Purpose of the Study:

• Review animal and human studies on probiotic interventions for hypertriglyceridemia.
• Summarize mechanisms by which probiotics reduce triglyceride levels.
• Explore the potential of next-generation probiotics.

Main Methods:

• Literature review of recent animal and human studies.
• Analysis of mechanisms involving gut microbiota, short-chain fatty acids, and bile acids.
• Discussion of challenges and prospects for probiotic application.

Main Results:

• Probiotics can impact intestinal lipid absorption and host lipid metabolism.
• Specific probiotic mechanisms involve metabolites like short-chain fatty acids and bile acids.
• Next-generation probiotics may offer enhanced therapeutic benefits.

Conclusions:

• Gut microbiota plays a significant role in hypertriglyceridemia.
• Probiotics, particularly next-generation strains, represent a promising avenue for managing hypertriglyceridemia.
• Further research is needed to overcome challenges and realize the full potential of probiotics.