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Cholinesterases in primary affective disorders.

J H Thakar, Y D Lapierre, B G Waters

Clinical Biochemistry

|October 1, 1985

Summary

This study found lower cholinesterase (ChE) and erythrocyte cholinesterase (AChE) activity in individuals with manic-depressive illness and their relatives. These findings suggest a role for cholinergic mechanisms in bipolar disorder and related affective disorders.

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Area of Science:

Neuroscience
Biochemistry
Psychiatry

Background:

Cholinergic systems are implicated in mood regulation.
Previous research suggests alterations in neurotransmitter systems in affective disorders.

Purpose of the Study:

To investigate cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) activity in patients with manic-depressive illness and their families.
To explore the potential role of cholinergic mechanisms in the etiology of affective disorders.

Main Methods:

Measurement of plasma cholinesterase (ChE) and intact erythrocyte acetylcholinesterase (AChE) activity.
Comparison of enzyme activities between patients with bipolar (BP), unipolar (UP), and other affective disorders (OA), their well first-degree relatives, and unrelated healthy volunteers.
Assessment of enzyme activity in BP patients on lithium treatment versus those not on treatment.

Main Results:

Significantly lower plasma cholinesterase (ChE) activity was observed in patients with BP, UP, OA, and well relatives from manic-depressive families.
Significantly lower intact erythrocyte cholinesterase (AChE) activity was found in all patient groups and their relatives.
Cholinesterase activities were similar in bipolar patients on lithium treatment compared to those not on lithium.

Conclusions:

The study indicates a significant role for cholinergic mechanisms in the pathophysiology of manic-depressive illness.
Reduced cholinesterase activity may represent a potential biomarker for affective disorders and their familial predisposition.
Findings suggest that cholinergic system dysregulation is involved in the etiology of bipolar and related mood disorders.

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