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Related Concept Videos

Teeth01:15

Teeth

731
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
731
Tooth Anatomy01:21

Tooth Anatomy

1.1K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Related Experiment Video

Updated: Sep 19, 2025

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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Vital Pulp Therapy in Permanent Teeth: A Systematic Review and Meta-Analyses.

James A Coll1, Vineet Dhar1, Marcio Guelmann2

  • 1Department of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, Baltimore, Md.

Pediatric Dentistry
|June 19, 2025
PubMed
Summary

Vital pulp therapy (VPT) methods show high success rates for teeth with normal pulp or reversible pulpitis. Full pulpotomy is a successful treatment option for teeth diagnosed with symptomatic irreversible pulpitis.

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Area of Science:

  • Endodontics
  • Dental Traumatology
  • Cariology

Background:

  • Vital pulp therapy (VPT) aims to maintain pulp vitality in permanent teeth.
  • Factors influencing VPT success require comprehensive evaluation to optimize clinical outcomes.

Purpose of the Study:

  • To systematically review and meta-analyze factors affecting the success of vital pulp therapy in permanent teeth.

Main Methods:

  • Systematic reviews of multiple databases were conducted up to June 2024.
  • The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach assessed the certainty of evidence.

Main Results:

  • Indirect pulp treatment (IPT), direct pulp capping (DPC), partial pulpotomy (PP), and full pulpotomy (FP) demonstrated high success rates (91-97%) for normal pulp/reversible pulpitis (NP/RP) at 24 months.
  • Full pulpotomy showed a 78% success rate at five years for teeth with symptomatic irreversible pulpitis (SIP), with significantly higher success in teeth without periapical pathosis.
  • Partial/full pulpotomy (PP/FP) success rates were comparable for traumatic pulp exposures versus direct pulp capping (DPC).

Conclusions:

  • All vital pulp therapy methods are effective for teeth diagnosed with normal pulp or reversible pulpitis.
  • Full pulpotomy is a viable and successful treatment option for permanent teeth diagnosed with symptomatic irreversible pulpitis.
  • Hemostasis within six minutes and the use of Biodentine may improve pulpotomy success rates.