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Role of the monkey orbitofrontal cortex in processing the choice history during reward-based decision-making
Moegi Higuchi1, Tsuyoshi Setogawa1,2, Takuto Izawa1
1System Emotional Science, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.
Cerebral Cortex (New York, N.Y. : 1991)
|June 19, 2025
Summary
Past choices influence decisions. The orbitofrontal cortex (OFC) uses history of choice-related factors (HCF) to guide current decision-making, impacting behavior and reaction times.
Area of Science:
- Neuroscience
- Cognitive Science
- Decision Science
Background:
- Decision-making is influenced by past experiences and choices.
- The orbitofrontal cortex (OFC) plays a crucial role in coding reward values.
- Previous research indicates OFC neuronal activity is modulated by prior reward outcomes.
Purpose of the Study:
- To investigate how the orbitofrontal cortex (OFC) processes the history of choice-related factors (HCF) from past decisions.
- To determine the neural mechanisms underlying the influence of past choices on current decision-making.
- To elucidate the role of OFC activity in integrating historical choice information.
Main Methods:
- Neuronal activity was recorded in the monkey OFC during a decision-making task.
- Computational models incorporating HCF were compared with models without HCF to explain neuronal activity.
- Pharmacological inactivation of the OFC using muscimol was performed to assess behavioral effects.
Main Results:
- Over 70% of OFC neurons showed activity better explained by models including HCF.
- Neuronal activity during current choices was significantly influenced by HCF from the previous trial.
- Choice reaction times differed significantly between trials based on HCF, an effect abolished by OFC inactivation.
Conclusions:
- History of choice-related factors (HCF) significantly modulates orbitofrontal cortex (OFC) neuronal activity.
- OFC activity integrates past choice information to guide ongoing decision-making and influence behavior.
- The OFC's role in processing choice history contributes to observed behavioral biases in decision-making.
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