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Updated: Sep 19, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Direct and Site-Selective C-H Cyanation of (Hetero)arenes by a Nontoxic Cyano Source
1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, P. R. China.
Abstract:
Direct C-H cyanation of arenes and heteroarenes is herein reported using a nontoxic cyano source with high regioselectivity. CuI serves as an essential multifunctional catalyst, which promotes the in situ generation of Cu-CN and aryl iodides and the subsequent cross-coupling of these two intermediates to yield aryl nitrile products. The new strategy of C-H cyanation, good regioselectivity, and the use of a nontoxic cyano source together represents a significant advancement in cyanation chemistry.
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