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Design optimization of longitudinal studies using metaheuristics: Application to lithium pharmacokinetics

Mitchell Aaron Schepps1, Jérémy Seurat2, France Mentré2

  • 1Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.

Statistical Methods in Medical Research
|June 19, 2025
PubMed
Summary

This study develops optimal designs to understand lithium pharmacokinetics in bipolar disorder patients. Findings will improve early identification of patients who respond well to lithium treatment.

Keywords:
Optimal design, lithiumbipolar disorder, Fisher information matrix, nonlinear mixed effects models, multiobjective

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