Sequelae of sural nerve biopsies.

Area of Science:

• Neurology
• Surgical Pathology

Background:

• Sural nerve biopsy is a common diagnostic procedure.
• Understanding its long-term sequelae is crucial for patient care.

Purpose of the Study:

• To evaluate the long-term consequences of sural nerve biopsy.
• To assess the incidence and severity of pain, dysesthesia, and sensory loss.

Main Methods:

• A retrospective study of 24 patients who underwent sural nerve biopsy.
• Assessment of persistent symptoms, including pain, dysesthesia, and hypesthesia, more than one year post-procedure.

Main Results:

• Fourteen patients (58%) reported persisting pain or dysesthesia over one year post-biopsy, with five experiencing severe symptoms.
• Seventeen of 18 patients (94%) with otherwise normal sensory function showed hypesthesia on the lateral aspect of the foot.
• Pain and dysesthesia were not significantly correlated with post-biopsy or generalized hypesthesia.

Conclusions:

• Sural nerve biopsy is associated with a significant incidence of long-term neuropathic symptoms.
• Persistent pain and dysesthesia, along with sensory deficits like hypesthesia, are common sequelae.
• These findings underscore the importance of informed consent and consideration of alternative diagnostic methods.