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A case report of phenytoin encephalopathy. Correlation between serum levels, seizure increase and E.E.G. spike and
Clinical Neurology and Neurosurgery
|January 1, 1985
Abstract:
In a case of phenytoin (PHT) encephalopathy a correlation was found between rising PHT serum levels and increase in seizure frequency. Supporting the correlation was the concomitant increase of E.E.G. spike and wave activity to 25% of the registration time. The rise in the PHT serum levels was possibly related to a drug interaction with carbamazepine. In addition neuropsychological assessment indicated reversible mental deterioration and deficits in motor skills and visual perception.