Hematological inflammation biomarkers in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma

To evaluate complete blood count and biochemical parameters in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG) and compare the results with healthy controls.

Forty-four patients with PEXS, 61 patients with PEXG, and 55 healthy subjects were enrolled in this retrospective study. All systemic and especially pseudoexfoliation-related ophthalmic examination findings of the participants were evaluated. Complete blood count, glucose, creatinine, and serum lipid values were obtained. In line with these data, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, monocyte-to-high density lipoprotein (HDL) ratio (MHR), and mean platelet volume-to-platelet count ratio were obtained and comparison were made among groups.

Diabetes mellitus and hypertension were significantly more common in the PEXS and PEXG groups than in the control group (P=0.021, P=0.016, respectively). In the analysis of complete blood count parameters, NLR and MHR values were statistically significantly higher in PEXS and PEXG compared to the control group (P=0.037, P=0.025, respectively). In addition, glucose, low-density lipoprotein, and triglyceride values were significantly higher in the PEXS and PEXG groups compared to the control group (P<0.001, P=0.035, P<0.001, respectively), and HDL value was significantly lower (P=0.031).

The hematological inflammation biomarkers we evaluated in our study provide evidence that systemic inflammation and oxidative stress processes play an important role in the pathogenesis of PEXS and PEXG.