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Research progress on NUSAP1 and its role in digestive system neoplasms
Shangui Fu1,2, Yuting Zhuo2, Tao Yu1
1Department of General Surgery, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, China.
Frontiers in Oncology
|June 19, 2025
Summary
Nucleolar spindle-associated protein 1 (NUSAP1) is crucial for cell division and is highly expressed in digestive cancers. Targeting NUSAP1 offers potential for new diagnostic and therapeutic strategies in oncology.
Area of Science:
- Molecular Biology
- Oncology
- Cell Biology
Background:
- Digestive system neoplasms have high incidence and mortality rates, necessitating novel therapeutic targets.
- Nucleolar spindle-associated protein 1 (NUSAP1) is a microtubule-binding protein vital for mitotic cell cycle regulation.
- NUSAP1 is increasingly recognized for its role in various malignant tumors.
Purpose of the Study:
- To review the structural characteristics, functional mechanisms, and signaling pathways of NUSAP1.
- To explore the specific functional mechanisms of NUSAP1 in digestive system neoplasms.
- To highlight NUSAP1's potential as a diagnostic marker and therapeutic target for digestive tumors.
Main Methods:
- Literature review focusing on NUSAP1's structure, function, and involvement in cell division.
- Analysis of studies investigating NUSAP1 expression in digestive system neoplasms.
- Exploration of signaling pathways modulated by NUSAP1 in tumorigenesis.
Main Results:
- NUSAP1 is highly expressed in various digestive system malignant tumors.
- NUSAP1 plays a pivotal role in tumor initiation, progression, treatment response, and prognosis.
- NUSAP1 links mitotic dysregulation to tumorigenesis through its effects on mitosis and signaling pathways.
Conclusions:
- NUSAP1 is a key molecule in the pathogenesis of digestive system neoplasms.
- NUSAP1 exhibits dual potential as a diagnostic biomarker and a therapeutic target for digestive cancers.
- Further research into NUSAP1 mechanisms may offer new perspectives for tumor diagnosis, treatment, and prognosis.
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