Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
Vector Algebra: Method of Components01:08

Vector Algebra: Method of Components

It is cumbersome to find the magnitudes of vectors using the parallelogram rule or using the graphical method to perform mathematical operations like addition, subtraction, and multiplication. There are two ways to circumvent this algebraic complexity. One way is to draw the vectors to scale, as in navigation, and read approximate vector lengths and angles (directions) from the graphs. The other way is to use the method of components.
In many applications, the magnitudes and directions of...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Vectors in Space: Problem Solving01:26

Vectors in Space: Problem Solving

A chandelier suspended by multiple cables can be analyzed using principles of three-dimensional static equilibrium. In this setup, a chandelier weighing 1000 N is positioned at the origin of a three-dimensional coordinate system, while three ceiling anchor points are fixed at known locations above it. Each cable connects the chandelier to one anchor point and transmits a tensile force along its length.To find out the forces in the cables, the spatial direction of each cable must first be...
Vectors in 2D: Problem Solving01:29

Vectors in 2D: Problem Solving

A plane traveling due north at 180 km/h in still air was found to be 80 km off-course after 30 minutes, deviating approximately 5 degrees east of north. This deviation means the influence of a crosswind alters the plane’s intended trajectory. The actual ground path formed a diagonal, suggesting that the aircraft’s effective ground speed was reduced to 160 km/h and directed slightly to the east due to the wind.By analyzing the displacement from the intended path, the velocity contributed by the...