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Updated: Sep 19, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
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Immune checkpoint inhibitor-induced thyroiditis and its potential mechanisms
Xueqian Mao1, Chaoming Mao1, Jiameng Liu1
1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Frontiers in Endocrinology
|June 19, 2025
Summary
Immune checkpoint inhibitors (ICIs) can cause thyroid dysfunction, a significant immune-related adverse event (irAE). Understanding ICI-induced thyroiditis mechanisms is crucial for improving cancer immunotherapy outcomes.
Area of Science:
- Oncology
- Immunology
- Endocrinology
Background:
- Immune checkpoint inhibitors (ICIs) are increasingly used in cancer therapy.
- Thyroid dysfunction is a common immune-related adverse event (irAE) associated with ICIs.
- Understanding the mechanisms of ICI-induced thyroiditis is essential for patient management.
Purpose of the Study:
- To systematically review the current understanding of the etiopathogenesis of ICI-induced thyroiditis.
- To explore the pharmacological aspects of ICIs and their role in thyroid autoimmunity.
- To analyze cellular and molecular factors contributing to thyroid dysfunction after ICI therapy.
Main Methods:
- Comprehensive literature review.
- Pharmacological characterization of ICIs.
- Multifactorial analysis of cellular and molecular contributors.
- Critical evaluation of pathogenic hypotheses.
Main Results:
- ICI therapy can lead to significant thyroid dysfunction.
- Multiple cellular and molecular pathways contribute to ICI-induced thyroid autoimmunity.
- Emerging hypotheses shed light on primary pathogenic drivers.
Conclusions:
- Mechanistic insights into ICI-induced thyroiditis are advancing.
- Establishing connections between ICI pharmacodynamics and thyroid immunopathology is key.
- Further research will aid in developing diagnostic and therapeutic strategies for ICI-related thyroid dysfunction.
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