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Updated: Sep 19, 2025

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
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A Diagnostically Challenging Case of Typical Hemolytic Uremic Syndrome Successfully Treated With Eculizumab Therapy

Adarsh Jha1, Georgette Nader1, Sumugdha Rayamajhi1

  • 1Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.

Cureus
|June 19, 2025
PubMed

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy that induces microvesicular injury and occlusion and often results in acute renal failure. Atypical HUS is life-threatening and often progresses to end-stage renal disease (ESRD). However, distinguishing between typical and atypical HUS can be challenging due to comorbid conditions and/or laboratory delays. We present a severe case of typical HUS involving a series of complications requiring multidisciplinary care, successfully treated with eculizumab therapy.

Keywords:
bleeding per rectumhemolysishemolytic uremic syndromemicroangiopathyschistocytes

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