Related Experiment Video

Updated: Sep 19, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.8K

Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells?

Barbora Judita Kasperova1,2, Anna Cinkajzlova3, Ludek Horvath1

  • 1Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia.

Frontiers in Cell and Developmental Biology
|June 19, 2025
PubMed

Insights

Cellular senescence, a hallmark of aging, contributes to obesity and type 2 diabetes. Targeting senescent cells offers a potential therapeutic strategy for these age-related metabolic diseases.

Area of Science:

  • Gerontology
  • Metabolic Diseases
  • Cellular Biology

Background:

  • Aging leads to physiological decline and increased disease risk.
  • Cellular senescence, a key aging process, is implicated in age-related diseases.
  • Obesity and type 2 diabetes are major chronic diseases linked to senescent cell accumulation.

Purpose of the Study:

  • To review the connections between aging, obesity, and type 2 diabetes.
  • To emphasize the role of cellular senescence in these diseases' development and progression.
  • To explore targeting cellular senescence as a therapeutic approach.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of the role of cellular senescence in metabolic dysfunction.
  • Discussion of senolytic therapies for age-related diseases.

Main Results:

  • Cellular senescence is a significant factor in the pathogenesis of obesity and type 2 diabetes.
  • Accumulation of senescent cells exacerbates metabolic dysfunctions associated with aging.
  • Targeting senescent cells shows promise in managing these interconnected conditions.

Conclusions:

  • Cellular senescence is a critical link between aging and metabolic diseases like obesity and type 2 diabetes.
  • Therapeutic strategies aimed at senescent cells could offer novel treatments.
  • Further research into senolytics may provide new avenues for prevention and management.
Keywords:
cellular senescencemetabolic complicationsobesitysenolyticstype 2 diabetes mellitus

More Related Videos

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.2K
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.6K

Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.2K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
15.1K
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
627
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
195