Green and efficient iron-catalyzed cross-dehydrogenative coupling for the synthesis of α,β-unsaturated ketones via
Manjit Singh1, Poonam Rajesh Prasad1
1Department of Chemistry, Institute of Science, Banaras Hindu University Varanasi UP 221005 India manjitsingh.rs.chy19@itbhu.ac.in poonamrp.chem@bhu.ac.in.
Abstract:
An efficient C-C cross-coupling approach for the synthesis of α,β-unsaturated ketones was developed through C(sp3)-H functionalization of acetophenone and methylarene under thermal conditions in the presence of a green catalyst, FeCl3·6H2O, with DMF as a solvent and atmospheric O2 (air) as an oxidant. The method was useful for a wide range of substrates, indicating good functional group compatibility and providing an innovative approach to forming new C-C bonds from inexpensive, readily available starting materials. Thus, the main advantages of the present methods are one-pot reactions, environmentally friendly approaches, cost-effectiveness, broad substrate scope, short reaction times, easy workup procedures, and good yields.
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