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Updated: Sep 19, 2025

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Structural Brain Changes Associated With Risky Drinking in Late-Life Depression.

David C Steffens1, Lihong Wang1, Kevin J Manning1

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Risky alcohol use in older adults with depression is linked to structural brain changes, particularly in frontal regions. Reducing alcohol consumption over time correlated with positive brain volume changes.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Alcohol use is prevalent among older adults experiencing depression.
  • Understanding the impact of alcohol consumption on brain structure in this demographic is crucial.

Purpose of the Study:

  • To assess structural brain changes over two years in older adults with depression.
  • To examine the association between changes in alcohol consumption and brain structure.

Main Methods:

  • A longitudinal cohort study involving 58 adults aged 60+ with major depressive episodes.
  • Structural MRI scans at baseline and 2-year follow-up, alongside assessments of alcohol consumption and cognitive function.

Main Results:

  • Risky drinkers (>7 drinks/week) exhibited thinner cortical thickness and smaller volumes in frontal regions compared to moderate drinkers.
  • Annualized changes in brain volume negatively correlated with changes in weekly alcohol consumption.
  • Improvements in depression, cognition, and reduced alcohol intake were associated with brain volume changes.

Conclusions:

  • Alcohol use adversely affects the fronto-striatal circuit in older adults with depression.
  • Highlights the importance of screening for and treating risky alcohol use in this population.