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Breast skin merkel cell carcinoma: a case report
Xinming Hou1, Qian Lv2, Zhaobao Lv1
1Department of Breast and Thyroid Surgery, The Second People's Hospital of Liaocheng Linqing 252600, Shandong, China.
American Journal of Translational Research
|June 19, 2025
Summary
Merkel cell carcinoma (MCC) is a rare skin cancer. This case highlights primary breast skin MCC with liver metastasis, requiring treatment adjustments due to side effects.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
- MCC is known for high rates of recurrence and metastasis.
Observation:
- A 65-year-old female presented with a rapidly growing breast mass, diagnosed as primary breast skin MCC.
- The mass evolved into a cauliflower-like lesion with pain.
Findings:
- Immunohistochemistry confirmed MCC with positive CK20, Synaptophysin, CD56, and CgA.
- PET-CT revealed liver metastasis.
- Chemotherapy showed initial efficacy but caused severe bone marrow suppression.
Implications:
- This case underscores the aggressive nature of MCC, even in rare locations like the breast skin.
- Treatment requires careful monitoring for side effects and potential therapy adjustments, such as switching to capecitabine maintenance therapy.
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