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Time Without Transfusion Reliance (TWiTR): Integrating Survival Quality Into Myelofibrosis Treatment Strategies Based
Ruben A Mesa1, Moshe Talpaz2, Flora Mazerolle3
1Atrium Health Wake Forest Baptist Comprehensive Cancer Center Winston-Salem North Carolina USA.
Introduction:
Myelofibrosis is characterized by debilitating constitutional symptoms and anemia, which negatively impact survival and quality of life. Red blood cell transfusions form the basis of anemia management in myelofibrosis but dependence on transfusions is further associated with poorer survival and quality of life.
Methods:
Time without transfusion reliance (TWiTR), a method integrating transfusion dependence and survival quality, was applied to three Phase 3 trials of momelotinib in myelofibrosis.
Results:
TWiTR demonstrated that patients treated with momelotinib versus comparators spent more time free from transfusions and anemia events.
Conclusion:
Momelotinib may lead to improved survival quality for patients with myelofibrosis.
Trial Registration:
ClinicalTrials.gov identifiers: NCT01969838, NCT02101268, and NCT04173494.
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