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Raman Spectroscopic Biodosimetry Using Protein in Murine Hair.

Spencer A Witte1, Monika Poonia1, Mallard Woodward1

  • 1Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio.

Radiation Research
|June 19, 2025
PubMed
Summary
This summary is machine-generated.

Raman spectroscopy of hair can detect ionizing radiation exposure. This biodosimetry method accurately determines radiation dose for rapid medical triage after accidental exposure.

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Area of Science:

  • Biophysics
  • Spectroscopy
  • Radiation Biology

Background:

  • Hair keratin is susceptible to damage from ionizing radiation.
  • Non-invasive biodosimetry is crucial for assessing radiation exposure.
  • Raman spectroscopy offers molecular-specific insights into biological tissues.

Purpose of the Study:

  • To assess changes in hair Raman spectra following ionizing radiation exposure.
  • To evaluate Raman spectroscopy as a biodosimetry tool for radiation exposure.
  • To develop models for predicting radiation dose from hair samples.

Main Methods:

  • Irradiated C57BL/6 mice (0-4 Gy gamma rays) were used.
  • Raman spectra were collected from mouse hair samples.
  • Partial least-squares discriminant analysis (PLS-DA) and PLS regression were applied.

Main Results:

  • Radiation-dependent spectral changes provided molecular signals of damage.
  • PLS-DA models achieved 80% accuracy in classifying exposed vs. control mice.
  • PLS regression yielded a dose-response model with RMSE ±1 Gy.

Conclusions:

  • Raman spectroscopy of hair is a viable method for radiation biodosimetry.
  • This technique can determine radiation dose from plucked hair samples.
  • It offers a potential tool for rapid medical triage after radiation incidents.