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Benefits of a Multifunctional Sunscreen Formulation Containing Nanoencapsulated Antioxidants in the Skin Protection
Ana Paula Fonseca1, Renata Ribon1, Lucia Cascais1
1Sallve Comércio de Cosméticos, São Paulo, SP, Brazil.
Background:
The development of sunscreens with properties beyond photoprotection involves carefully optimizing the blend of ingredients and employing advanced systems to ensure effective delivery through the skin layers.
Aims:
The aim of this study was to evaluate the efficacy of a multifunctional photoprotective formulation containing a blend of nanoencapsulated ingredients-ascorbyl palmitate, caffeine, and resveratrol-and the active ingredients niacinamide, hyaluronic acid, bisabolol, tocopherol, and carnosine in skin protection against UV and blue light radiations, by in vitro, ex vivo, and clinical studies.
Methods:
A preclinical approach using human explants was performed to evaluate the protective effects of a sunscreen formulation against damage induced by UV and blue light radiation. In addition, a clinical trial was carried out to evaluate skin acceptability, protection from UV-A and UV-B, collagen synthesis by fluorescence spectroscopy, and skin hydration.
Results:
The results of the preclinical study showed that the proposed formulation prevented UV-induced reactive oxygen species (ROS) production and stimulated the levels of epidermal opsin-3 photoreceptors, ensuring melanogenesis control. The clinical study showed that the sunscreen was well-tolerated by both skin and eyes, improved skin conditions by upregulating collagen synthesis, and moisturizing the skin.
Conclusion:
The combination of the active ingredients in the proposed formulation was safe and effective for skin protection against ultraviolet radiation, besides promoting collagen synthesis and opsin-3 stimulus.
