Nonablative Fractional 1927-nm Laser for Periorbital Rejuvenation: A Prospective, Double-Arm, Open-Label Trial

The 1927-nm nonablative fractional laser is widely used for skin rejuvenation and hyperpigmentation. However, its efficacy and safety for periorbital rejuvenation remain uncertain.

To assess the effects of the 1927-nm nonablative fractional diode laser on periorbital rejuvenation.

Twenty participants were randomized into two groups and received three treatments at 2-week (Group A) or 4-week (Group B) intervals. Clinical efficacy was assessed using ANTERA 3D, blinded investigator-rated scores, and subject self-assessments.

Both group A and group B exhibited statistically significant improvements in L* (color measurement which indicates lightness) and pigmentation score at the end-of-study visit compared to baseline, with group B also achieving statistically significant enhancement in the pores' index and wrinkles' score. Group B showed greater improvement in wrinkles' score compared to group A at the end-of-study visit. The median of Global Aesthetic Improvement Scale assessed by both the physicians and subjects showed improvement, ranging from "improved" to "much improved" at the end-of-study visit. Transient side effects including tenderness, erythema, swelling, and scaling were observed, with the majority resolving within 7 days.

The 1927-nm diode laser is an effective and safe option for periorbital rejuvenation. The 4-week interval treatment appears to be the preferable option due to its superior improvement in the wrinkles' score at the end of the study. The positive changes in skin brightness and the reduction of brown spots represented additional benefits, setting it apart as a notable alternative to other ablative and nonablative fractional lasers.