Related Experiment Video
Updated: Sep 19, 2025

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer
Deepak S Chauhan1,2, Kun Shao3, Roopa Hebbandi Nanjundappa1
1Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Abstract:
Photo-responsive/activable nanomedicine-driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, these therapies significantly enhance anti-cancer efficacy. This comprehensive review examines the current advancements in photo-responsive/activable immunomodulator-loaded nanomedicines (PINs), providing a detailed analysis of their preclinical development, clinical translation, and associated research funding. The diverse PINs are systematically categorized, innovative design strategies are explored, and the underlying photo-responsive/activable and immunomodulatory mechanisms are elucidated. By integrating clinical advancements with technical innovations and financial perspectives, this review bridges the translational gap, underscoring the immense potential of PINs to revolutionize cancer therapy. This comprehensive resource is indispensable for researchers striving to bring phototherapies to clinical fruition in the battle against cancer.
Related Concept Videos
Tumor Immunotherapy
Cancer Survival Analysis
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

