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The value of plasma immunoproteasome for predicting coronary collateral circulation in ST-elevation myocardial

Zhao Ma1, Meichen Sun1, Baoen Zhang1

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.

Biomarkers in Medicine
|June 19, 2025
PubMed

Insights

Higher levels of the immunoproteasome component LMP7 predict good coronary collateral circulation (CCC) in ST-elevation myocardial infarction (STEMI) patients. This suggests LMP7 may serve as a biomarker for collateral development after heart attack.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarker Discovery

Background:

  • The immunoproteasome influences endothelial function and angiogenesis.
  • Coronary collateral circulation (CCC) is crucial for outcomes in ST-elevation myocardial infarction (STEMI).

Purpose of the Study:

  • To investigate the predictive value of immunoproteasome components for CCC in STEMI patients.
  • To identify potential biomarkers for assessing collateral development post-myocardial infarction.

Main Methods:

  • Plasma levels of immunoproteasome components (LMP2, LMP7, PSMB10) were measured in 252 STEMI patients.
  • Receiver operating characteristic (ROC) curves, logistic regression, and restricted cubic spline (RCS) analyses were employed.
  • Predictive ability for good CCC was assessed, along with dose-response relationships.

Main Results:

  • STEMI patients with good CCC exhibited significantly higher plasma immunoproteasome levels.
  • LMP7 demonstrated the strongest predictive value (AUC = 0.732) for good CCC, with an optimal cut-off of 3.824 ng/mL.
  • Elevated LMP7 (≥3.824 ng/mL) was an independent predictor of good CCC, showing a J-shaped association.

Conclusions:

  • Increased plasma immunoproteasome levels, particularly LMP7, are independently associated with good CCC in STEMI.
  • LMP7 shows promise as a predictive biomarker for coronary collateralization in patients with myocardial infarction.
Abstract

Keywords:
ImmunoproteasomeST-elevation myocardial infarctioncoronary collateral circulationrestricted cubic spline

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