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Lactobacillus johnsonii HL79 mitigate plateau environment-induced hippocampal dysfunction in mice
Baoxing Gan1, Xufei Zhang2, Jinge Xin3
1Animal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, No. 211 Huimin Road, Wenjiang District, Chengdu, Sichuan, China.
AMB Express
|June 19, 2025
Summary
Probiotic HL79 partially improved memory and reduced hippocampal damage in mice exposed to simulated high-altitude plateau environments. The intervention modulated lipid metabolism and signaling pathways, offering a potential strategy for plateau adaptation.
Area of Science:
- Physiology
- Microbiology
- Neuroscience
Background:
- Plateau environments present multistress conditions (hypoxia, cold, radiation) impacting human health.
- High-altitude exposure affects brain function and gut microbiota, but mechanisms linking them are unclear.
- The microbiota-gut-brain axis is crucial for understanding adaptation to extreme environments.
Purpose of the Study:
- To investigate if probiotic HL79 can mitigate hippocampal impairments caused by simulated plateau conditions in mice.
- To explore the effects of probiotic intervention on the microbiota-gut-brain axis under high-altitude stress.
Main Methods:
- Mice were exposed to simulated plateau environments (3500-4000m).
- Cognitive function, hippocampal oxidative stress, and synaptic plasticity biomarkers were assessed.
- Hippocampal transcriptomics and serum metabolomics were performed after probiotic HL79 administration.
Main Results:
- Simulated high-altitude exposure induced memory deficits, oxidative stress, and altered synaptic plasticity markers in mice.
- Probiotic HL79 administration partially alleviated memory dysfunction and hippocampal tissue damage.
- HL79 modulated hippocampal lipid metabolism gene expression and altered serum metabolites in pathways like bile secretion and linoleic acid metabolism.
Conclusions:
- Probiotic intervention shows potential for ameliorating high-altitude-induced hippocampal impairments.
- HL79's benefits may stem from modulating lipid metabolism and related signaling pathways.
- This study offers a microbiota-gut-brain axis-based strategy for plateau environment adaptation.
