Gene Dynamics in Maternal Nutrition: The Role of Chromium in Mitigating Offspring Obesity
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View abstract on PubMed
Summary
This summary is machine-generated.Maternal chromium supplementation reduced offspring obesity by altering gene expression in adipose tissue. This nutritional strategy offers potential for preventing intergenerational metabolic disorders.
Area Of Science
- Nutritional epigenetics
- Metabolic disorders
- Obesity research
Background
- Maternal nutrition significantly impacts offspring metabolic health.
- Chromium (Cr) plays a role in glucose and lipid metabolism.
- Intergenerational obesity is a growing public health concern.
Purpose Of The Study
- To elucidate the molecular mechanisms by which maternal chromium supplementation mitigates offspring obesity.
- To identify key regulatory genes involved in chromium's protective effects.
- To explore potential therapeutic targets for intergenerational obesity prevention.
Main Methods
- Mice dams were supplemented with chromium (Cr) or control diets during gestation and lactation.
- Offspring received Cr diets post-weaning until 32 weeks of age.
- Adipose tissue gene expression was analyzed using GEO2R, functional enrichment, and protein-protein interaction network analysis.
Main Results
- Chromium supplementation significantly reduced offspring adipose tissue mass.
- 136 differentially expressed genes (DEGs) were identified in offspring adipose tissue.
- DEGs were involved in lipid metabolism, steroid hormone biosynthesis, and fatty acid oxidation.
- 14 hub genes, including ACSL1, DGAT1, and PPARG, were identified as central to adipocyte regulation and lipid accumulation suppression.
Conclusions
- Maternal chromium supplementation protects against offspring obesity by modulating key genes involved in lipid metabolism.
- The identified gene network provides a framework for developing nutritional and pharmacological interventions for obesity prevention.
- Chromium's effects on epigenetic regulation of lipid metabolism are crucial for intergenerational metabolic health.
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