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Updated: Sep 19, 2025

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Epidemiologic trends for pediatric Hodgkin and non-Hodgkin lymphomas: a U.S. population-based study

Weishi Cheng1, Xu Sun2, Shijie Yang3

  • 1Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Annals of Hematology
|June 19, 2025
PubMed

Insights

Pediatric lymphoma incidence increased after 2003, with rising prevalence. In contrast, adult lymphoma incidence decreased, and mortality rates declined significantly over four decades, showing a positive trend in pediatric cancer outcomes.

Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Pediatric Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) differ from adult forms and are less common.
  • Understanding trends in pediatric and adult lymphoma incidence, prevalence, and mortality is crucial for public health strategies.

Purpose of the Study:

  • To analyze and compare the epidemiological trends of pediatric and adult lymphoma from 1975 to 2018.
  • To assess changes in incidence, prevalence, and mortality rates for both pediatric and adult lymphoma populations.

Main Methods:

  • Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database (1975-2018).
  • Analyzed age-adjusted incidence, prevalence, and mortality rates for pediatric (7,871 cases) and adult (226,211 cases) lymphoma.
  • Calculated annual percentage change (APC) to identify trends over specific periods.

Main Results:

  • Pediatric lymphoma incidence showed no significant change from 1975-2002 but increased after 2003 (APC = +1.31).
  • Pediatric lymphoma prevalence rates increased, with 5-year rates rising and 20-year rates showing a consistent upward trend.
  • Adult lymphoma incidence decreased in recent years, while mortality rates, after an initial rise, showed a significant decline after 1994 (APC = -0.49).
  • Pediatric lymphoma mortality rates consistently decreased over four decades (APC = -3.12).

Conclusions:

  • Pediatric lymphoma incidence has shown an increasing trend in recent years, accompanied by rising prevalence.
  • Adult lymphoma trends show a decrease in incidence and a significant decline in mortality, indicating improved outcomes.
  • The consistent decrease in pediatric lymphoma mortality over four decades suggests positive developments in treatment or care, despite increasing incidence.

Keywords:
IncidenceMortalityPediatric lymphomaPrevalence

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