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Lactate and lactylation modifications in neurological disorders
Yu Gu1, Keyang Chen, Chunyan Lei
1First Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Neural Regeneration Research
|June 19, 2025
Summary
Lactate, a metabolic byproduct, is a key signaling molecule in the brain. Research highlights lactylation modifications and abnormal lactate metabolism in neurological diseases, offering potential therapeutic targets.
Area of Science:
- Biochemistry
- Neuroscience
- Molecular Biology
Background:
- Post-translational modifications regulate protein function beyond abundance.
- Lactate is increasingly recognized as a critical signaling molecule in the nervous system.
- Neurological diseases involve complex metabolic and regulatory pathways.
Purpose of the Study:
- To review current research on lactate and lactylation in neurological diseases.
- To clarify the mechanisms of lactate's action and its modifications in the brain.
- To identify potential therapeutic targets for neurological disorders.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of lactate metabolism and lactylation mechanisms.
- Examination of lactate's role in various neurological conditions.
Main Results:
- Lactate plays a significant role in brain function and neurological disease progression.
- Lactylation, including histone and non-histone modifications, is a key regulatory process.
- Abnormal lactate metabolism is implicated in diseases like Alzheimer's, Parkinson's, and stroke.
Conclusions:
- Lactate acts as a crucial signaling molecule in brain function.
- Lactylation modifications are vital for understanding neurological health and disease.
- Further research into lactate and lactylation mechanisms may yield novel therapeutic strategies.
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