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Related Concept Videos

Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Classification of Illness01:17

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The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
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Factors Affecting Illness01:18

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
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Depressive Disorders: MDD and Dysthymia01:27

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Muscle Recovery and Fatigue01:24

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Updated: Sep 19, 2025

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

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Multidimensional Characterization of Long COVID Fatigue.

Matthew B Maas1,2,3, Kathryn J Reid1,2, Millenia Jimenez1

  • 1Department of Neurology, Northwestern University, Chicago, IL, USA.

Behavioral Sleep Medicine
|June 19, 2025
PubMed
Summary
This summary is machine-generated.

Post-acute sequelae of SARS-CoV-2 infection (PASC) fatigue is linked to disrupted sleep, circadian rhythms, and depression. Addressing these factors may help manage PASC fatigue symptoms.

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Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Infectious Diseases

Background:

  • Post-acute sequelae of SARS-CoV-2 infection (PASC), commonly known as long COVID, presents with persistent, disabling symptoms.
  • Fatigue is a predominant and often debilitating symptom in PASC patients, significantly impacting quality of life.

Purpose of the Study:

  • To characterize the phenotype of PASC fatigue through a multidimensional analysis.
  • To investigate the associations between fatigue severity and mood, cognition, sleep, and circadian rhythms in PASC patients.

Main Methods:

  • Recruited adult PASC patients from a Neuro-COVID-19 Clinic.
  • Assessed self-reported symptoms using Patient-Reported Outcomes Measurement Information System (PROMIS) instruments.
  • Evaluated cognitive performance with NIH Toolbox measures, sleep, and rest-activity rhythms via 7-day wrist actigraphy, and polysomnography in a subset.

Main Results:

  • Fatigue severity correlated with worse subjective cognitive abilities, depression symptoms, disrupted rest-activity patterns, and increased sleep time.
  • Objective cognitive performance was not significantly correlated with fatigue severity.
  • Multivariable analysis identified independent associations between fatigue and subjective cognition, depression, and circadian rhythm disruption.

Conclusions:

  • Long sleep times, disrupted circadian patterns, depression, and subjective cognitive impairment are associated with PASC fatigue.
  • Behaviorally influenced sleep and circadian abnormalities may exacerbate PASC fatigue and represent potential therapeutic targets.