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Sex-Specific Differences in Management and Outcomes of Cardiogenic Shock Patients With and Without Ischemic

Ik Hyun Park1, Chang Hoon Kim2, Woo Jin Jang3

  • 1Department of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Korean Circulation Journal
|June 19, 2025
PubMed

Insights

Sex does not significantly impact cardiogenic shock (CS) management or mortality, regardless of whether ischemic cardiomyopathy (ICMP) is present. This study found comparable outcomes for both male and female patients with CS.

Area of Science:

  • Cardiology
  • Clinical Research
  • Sex-Based Medicine

Background:

  • Limited data exists on sex-based differences in cardiogenic shock (CS) management and outcomes.
  • Investigating these differences is crucial for personalized patient care.
  • Stratification by underlying etiology, such as ischemic cardiomyopathy (ICMP), is necessary.

Purpose of the Study:

  • To determine if clinical management and outcomes in patients with CS differ between sexes.
  • To analyze these differences stratified by CS etiology (ICMP vs. non-ICMP).

Main Methods:

  • Analysis of 1,247 CS patients from the multicenter RESCUE registry.
  • Stratification by sex and CS etiology (ICMP and non-ICMP).
  • Utilized multivariable Cox proportional hazards models and propensity-score matching for analysis.

Main Results:

  • Among ICMP patients, females underwent coronary angiography less frequently, but revascularization success rates were similar.
  • In-hospital 30-day mortality was comparable between sexes in both ICMP and non-ICMP groups.
  • 12-month mortality risk also remained similar between sexes across both etiological groups.

Conclusions:

  • No significant sex-based differences were observed in the management of CS.
  • In-hospital and 12-month mortality rates were comparable between females and males with CS.
  • These findings hold true irrespective of the underlying etiology of CS.
Abstract

Keywords:
CardiomyopathiesEtiologyPrognosisSex characteristicsShock, cardiogenic

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