Green-engineered multispectral analytical approaches for simultaneous quantification of amoxicillin and diclofenac in pure and combined forms
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View abstract on PubMed
Summary
This summary is machine-generated.This study introduces five new spectrophotometric methods for simultaneously analyzing amoxicillin trihydrate and diclofenac sodium. These validated, eco-friendly techniques offer a rapid and reliable quality control solution for pharmaceutical formulations.
Area Of Science
- Analytical Chemistry
- Pharmaceutical Analysis
- Green Chemistry
Background
- Increasing demand for sustainable and high-throughput analytical methods.
- Challenges in simultaneously determining drugs with overlapping UV spectra.
- Need for validated, cost-effective quality control procedures in pharmaceutical analysis.
Purpose Of The Study
- To develop and validate five innovative univariate spectrophotometric methods.
- To enable simultaneous determination of amoxicillin trihydrate and diclofenac sodium.
- To assess the environmental impact and greenness of the developed analytical protocols.
Main Methods
- Development of five univariate spectrophotometric methods: first derivative, second derivative, ratio difference, ratio derivative, and ratio subtraction.
- Optimization and validation according to ICH Q2(R1) guidelines.
- Greenness assessment using GAPI, NEMI, and Analytical eco scale.
Main Results
- Successful simultaneous determination of amoxicillin trihydrate and diclofenac sodium in synthetic mixtures and pharmaceutical dosage forms.
- Methods demonstrated excellent linearity, accuracy, precision, and robustness.
- All developed methods were confirmed to be eco-friendly, validating their green nature.
Conclusions
- The developed spectrophotometric methods are suitable for routine quality control of amoxicillin trihydrate and diclofenac sodium.
- These methods provide a cost-effective, rapid, and green alternative for pharmaceutical analysis.
- The study successfully balances analytical reliability with environmental responsibility.
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