Related Experiment Video
Updated: Sep 18, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Age-period-cohort analysis of past 12-month cannabis use in Germany (1995-2021)
Natalie S Schöllner1, Adrian Glos1, Justin Möckl2,3
1Institut für Statistik, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.
Background And Aims:
In 2024, cannabis was partially legalized for recreational purposes in Germany. With a growing prevalence of persons who used cannabis in the past 12 months, and the health risks associated with cannabis use, it is imperative to examine usage behavior patterns in greater detail. The present analysis measured the impact of age, time period and birth cohort on the prevalence of cannabis consumption in the past 12 months in Germany.
Design:
Longitudinal study using data from 10 waves (1995-2021) of the German Epidemiological Survey of Substance Abuse (ESA), a cross-sectional nationally representative household survey of individuals between the ages of 18 and 59 or 64 years.
Setting:
Germany.
Participants:
Ntotal = 78 678 German-speaking adults between the ages of 18 and 59 years.
Measurements:
Self-report of cannabis use in the last 12 months as well as alcohol use and smoking conventional tobacco products in the last 30 days.
Findings:
We employed binary logistic regression using a generalized additive model to examine age, period and cohort effects, as well as covariate effects on past 12-month cannabis use. Over time, both period and cohort had an increasing effect, while an increase in age corresponded to a decrease in prevalence. Specifically, the odds ratio (OR) for cannabis use decreased from 9.44 [95% confidence interval (CI) = 8.17-10.9] at age 18 years to 0.13 (95 CI = 0.10-0.17) at age 59 years. Period effects also showed an increase, with the OR rising from 0.33 (95% CI = 0.26-0.43) in 1995 to 2.96 (95% CI = 2.55-3.43) in 2021, while cohort effects increased from 0.02 (95% CI = 0.001-0.05) for those born in 1936 to 16.69 (95% CI = 13.8-20.8) for those born in 2002. Additionally, persons using cannabis had a higher likelihood of also drinking alcohol and smoking conventional tobacco products in the last 30 days.
Conclusions:
In Germany, the odds of being a past-12-month cannabis consumer appears to decline with increasing age, indicating that only a small proportion of consumers engage in cannabis use throughout their whole lives, with a peak prevalence occurring at a younger age.
Related Concept Videos
Longitudinal Research
Drug Concentration Versus Time Correlation
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
An Overview of Psychoactive Drugs
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Analysis of Population Pharmacokinetic Data
Time Course of Drug Effect
Cancer Survival Analysis

