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Published on: December 9, 2022
Mesencephalic astrocyte-derived neurotrophic factor: a potential diagnostic marker in human sepsis-associated lung
Yan Zhou1, Ni Yao1, Jing-Wen Zheng2,3
1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, PR China.
Abstract:
Systemic inflammatory response syndrome (SIRS) commonly considered as the first step in the sepsis cascade. To evaluate the diagnostic value and potential mechanism of serum MANF in sepsis-associated lung injury (SALI), 15 adult SALI patients and 15 age- and sex-matched SIRS patients were enrolled to measure serum MANF levels by sandwich enzyme-linked immune-sorbent assay and the laboratory indexes including C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) were collected. MANF and IL-6 levels showed significant differences between groups (P < 0.05), and the area under the curve (AUC) values of MANF and IL-6 were 0.822 and 0.815. The combination of MANF with IL-6 exhibited improved predictive accuracy for SALI. Furthermore, we found that there is a protein interaction network between MANF and all of these overlap targets between ferroptosis-related genes (FRGs) and SALI by bioinformatics analysis. MANF could be a promising biomarker for the differential diagnosis of SALI and SIRS.
