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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Multidisciplinary Management Improves Re-Admission, Major Amputation, and Mortality Rates in Patients with Diabetic
Chi-Wei Chiu1,2, Wen-Teng Yao1,2,3,4, Chieh-Ming Yu1,2,3
1Division of Plastic Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
A multidisciplinary diabetic foot care center (MDDFCC) significantly reduced 1-year re-admission, major amputation, and disease-specific mortality for diabetic foot ulcers (DFUs). This integrated approach improves patient outcomes and offers a potential model for DFU management.
Area of Science:
- Podiatry
- Endocrinology
- Vascular Surgery
- Wound Care
Background:
- Diabetic foot ulcers (DFUs) represent a significant complication of diabetes, leading to high rates of morbidity and mortality.
- Effective management of DFUs requires a comprehensive, often multidisciplinary, approach to address the complex underlying factors.
- The establishment of specialized centers aims to consolidate expertise and resources for optimal DFU care.
Purpose of the Study:
- To evaluate the impact of a multidisciplinary team (MDT) approach on DFU management outcomes.
- To compare re-admission, amputation, and mortality rates before and after the implementation of a multidisciplinary diabetic foot care center (MDDFCC).
Main Methods:
- A retrospective analysis comparing DFU patient outcomes before and after the opening of an MDDFCC in August 2018.
- Outcomes assessed included 1-year re-admission, major amputation, and disease-specific mortality rates.
- Statistical analysis, including hazard ratios (HR) and 95% confidence intervals (CI), was used to determine the significance of various factors.
Main Results:
- Patients managed at the MDDFCC demonstrated a significantly lower risk of 1-year re-admission (HR=0.697), major amputation (HR=0.447), and disease-specific mortality (HR=0.277).
- Factors associated with 1-year major amputation included higher PEDIS scores, history of dialysis, and consultations with physiatrists, orthopedists, and social workers.
- Factors associated with 1-year disease-specific mortality included major amputation, older age, and elevated C-reactive protein levels.
Conclusions:
- The multidisciplinary diabetic foot care center (MDDFCC) approach is an effective organizational structure for treating diabetic foot ulcers.
- This integrated model leads to significant improvements in key outcomes, including reduced re-admission, amputation, and mortality rates.
- The MDDFCC facilitates more aggressive and timely interventions, such as surgical procedures and percutaneous transluminal angioplasty, alongside robust medical care.
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