Rare Ocular Association With Hailey-Hailey Disease.

Area of Science:

• Dermatology
• Ophthalmology

Background:

• Hailey-Hailey disease is an autosomal dominant blistering disorder affecting epidermal keratinocytes.
• It typically presents with vesiculobullous eruptions in intertriginous areas.
• Ocular involvement is an uncommon manifestation.

Observation:

• A 12-year-old female with a history of recurrent blisters presented with bilateral eye redness, irritation, and watering.
• Slit lamp examination revealed conjunctival congestion, peripheral corneal neovascularization, reduced corneal luster, and corneal haze.
• Ocular signs were more pronounced in the left eye.

Findings:

• Differential diagnoses including pemphigus vulgaris and allergic conjunctivitis were excluded based on clinical presentation and biopsy.
• The patient received treatment with topical corticosteroids, lubricants, and ointment.
• Follow-up demonstrated reduced conjunctival congestion, improved corneal luster, and symptomatic relief.

Implications:

• This case underscores the rare but significant ocular manifestations of Hailey-Hailey disease.
• Early recognition and management of ocular symptoms are crucial to prevent vision-impairing sequelae.
• The early onset in this pediatric case highlights the need for heightened awareness in younger patients.