Interacting and joint effects of triglyceride-glucose index and body mass index on future endometrial cancer risk and the mediating role of body mass index: a cross-sectional study
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View abstract on PubMed
Summary
This summary is machine-generated.A higher triglyceride-glucose (TyG) index, indicating insulin resistance, is linked to increased endometrial cancer risk. Body mass index (BMI) significantly mediates this association, highlighting its role in metabolic-related cancer development.
Area Of Science
- Endocrinology
- Oncology
- Metabolic Syndrome
Background
- The triglyceride-glucose (TyG) index is a key indicator of insulin resistance.
- Insulin resistance is associated with various metabolic-related cancers.
- Limited data exists on the TyG index's role in endometrial cancer subtypes and mediating factors.
Purpose Of The Study
- To investigate the association between the TyG index and endometrial cancer risk.
- To explore the mediating role of clinical factors, particularly BMI, in this relationship.
Main Methods
- Cross-sectional study involving 1,194 female participants.
- Multivariate logistic regression analyses to assess TyG index and endometrial cancer risk.
- Mediation effects evaluated using established statistical methods.
Main Results
- A higher TyG index was significantly associated with an increased risk of endometrial cancer (OR: 1.93).
- Body mass index (BMI) significantly mediated the association between TyG index and endometrial cancer risk (25-41% mediation).
- No correlation was observed between TyG index and specific endometrial cancer clinical characteristics.
Conclusions
- Elevated TyG index, reflecting insulin resistance, is linked to higher endometrial cancer risk.
- BMI plays a significant mediating role in the TyG index-endometrial cancer association.
- Further prospective studies are warranted to confirm these findings.
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