Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Long vs. short axial field-of-view PET scanners for brain imaging: a phantom study.

Frontiers in nuclear medicine·2026
Same author

Total Body PET.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same author

Validation of a Deep-Learning Coregistration Framework for Long-Axial-Field-of-View PET/CT Using Low-Radiation-Exposure Protocols Across Various Tracers.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Delayed [<sup>89</sup>Zr]Zr-<i>N</i>-Succinyldesferal-Trastuzumab Imaging Enabled by Long-Axial-Field-of-View PET/CT.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Influence of Ultra-Low-Dose CT on PET Image Quantification and Visual Assessment.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025

Related Experiment Video

Updated: May 9, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

14.1K

Evaluating image-derived input functions for cerebral [18F]MC225 PET studies.

Giordana Salvi de Souza1,2, Pascalle Mossel1,3, Joost F Somsen1

  • 1Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Frontiers in Nuclear Medicine
|June 20, 2025
PubMed
Summary

Arterial samples remain essential for calibrating the image-derived input function (IDIF) and accurately estimating brain volume of distribution (VT) with [18F]MC225 PET. Internal carotid artery (ICA) derived IDIF, when calibrated, offers reliable VT results.

Keywords:
IDIFkinetic analyseslong axial field of view PETpharmacokineticsquantitative analysisvenous sampling

More Related Videos

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.5K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.3K

Related Experiment Videos

Last Updated: May 9, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

14.1K
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.5K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.3K

Area of Science:

  • Nuclear Medicine
  • Radiochemistry
  • Neuroimaging

Background:

  • Kinetic modeling of brain Positron Emission Tomography (PET) data is vital for quantitative biological parameter estimation.
  • Traditionally, arterial blood sampling is required for accurate input function measurement.
  • Developing methods to omit arterial sampling is a key goal in PET imaging research.

Purpose of the Study:

  • To evaluate the feasibility of omitting arterial samples for estimating the image-derived input function (IDIF) using a long axial field-of-view PET scanner.
  • To assess the utility of internal carotid arteries (ICA) for IDIF estimation and venous samples for plasma parameters.
  • To compare different IDIF calibration methods and their impact on VT estimation for the [18F]MC225 tracer.

Main Methods:

  • PET scans with [18F]MC225 were performed on healthy volunteers with manual arterial sampling.
  • Image-derived input functions (IDIFs) were generated from the aortic arch (IDIFAA) and calibrated with arterial samples (IDIFAA_CAL).
  • ICA-derived IDIFs were also calibrated (IDIFICA_CAL) and compared; venous samples were used to assess plasma-to-whole blood ratios and parent fractions.

Main Results:

  • Direct IDIFAA estimation showed discrepancies with arterial samples, underscoring the need for calibration.
  • Calibrated IDIFAA,P resulted in a 4.0% difference in brain VT compared to uncalibrated IDIFAA,P.
  • ICA-derived IDIFICA_CAL,P demonstrated strong agreement with arterial-calibrated IDIFAA_CAL,P, with only a 1.2% VT difference.
  • Venous sampling provided reliable plasma parameters but was unsuitable for IDIF calibration, leading to a significant 39% VT difference.

Conclusions:

  • Arterial samples are indispensable for accurate IDIF calibration and reliable VT estimation in [18F]MC225 PET studies.
  • Calibrated IDIF derived from the internal carotid artery (ICA) provides accurate VT estimates.
  • While venous sampling can replace arterial sampling for plasma parameters, it is not suitable for IDIF calibration.