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Efficacy of microbial cell-free DNA testing for detecting pathogens in pediatric patients with head and neck
Audrey Xu1, Andrea Miranda2, Hung Fu Lin2
1Program in Human Biology, School of Humanities & Sciences Stanford University Stanford California USA.
Abstract:
We investigate the utility of microbial cell-free DNA (mcfDNA) from the blood to predict surgical culture results. In this study, only 26.9% of patients had mcfDNA results that were considered predictive of the causative organism(s). There was a significant burden of contamination in the cohort, emphasizing that dedicated protocols must be followed when running gene-based diagnostics. Healthy patients showed detectable mcfDNA signals, though typically at lower molecules per milliliter for similar pathogens.
