Jove
Visualize
Contact Us

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

611
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
611

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in antioxidant activities of edible mushroom polysaccharides: status, influencing factors, mechanisms, and applications.

Frontiers in nutrition·2026
Same author

A Reproducible Multichannel Synchronous Rapid Phosphopeptide Enrichment Strategy Enabled by Anisotropic Porous Chitosan-Based Arrays.

Analytical chemistry·2026
Same author

A Dual-Role Transcription Factor FpCys3 Couples Glucose Sensing to Methionine Biosynthesis and Virulence in Fusarium pseudograminearum.

Plant, cell & environment·2026
Same author

Global landscape of yttrium-90 clinical trials: a systematic registry-based analysis.

Trials·2026
Same author

Case Report: Novel compound heterozygous mutations in <i>PNPLA6</i> gene associated with Oliver-McFarlane syndrome.

Frontiers in genetics·2025
Same author

Association of blood trace minerals and nocturia in young and middle-aged adults: a cross-sectional study based on NHANES.

Frontiers in nutrition·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 18, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.4K

Altered gut microbiota in erectile dysfunction patients: a pilot study.

Quanxin Su1, Kenan Wang1, Yayin Luo2

  • 1Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

Frontiers in Microbiology
|June 20, 2025
PubMed
Summary

Gut microbiota alterations, including decreased Bacteroides intestinalis and increased Ruminococcus gnavus, are linked to erectile dysfunction (ED). These changes may influence ED pathogenesis through atherosclerosis and amino acid metabolism, suggesting potential for microbiota-targeted therapies.

Keywords:
Bacteroides intestinaliserectile dysfunctiongut microbiotamacrogenomicsmetabolic pathways

More Related Videos

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.5K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.7K

Related Experiment Videos

Last Updated: Sep 18, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.4K
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.5K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.7K

Area of Science:

  • Microbiome Research
  • Human Health and Disease
  • Metabolic Pathways

Background:

  • The gut microbiota's influence on health and disease is increasingly recognized.
  • The specific role of gut microbiota in erectile dysfunction (ED) remains largely unexplored.
  • Understanding these connections is crucial for advancing ED pathogenesis research.

Purpose of the Study:

  • To investigate and compare gut microbiota composition and metabolic pathways in males with ED versus healthy controls.
  • To identify potential microbial biomarkers associated with ED.
  • To explore the contribution of gut microbiota alterations to ED pathogenesis.

Main Methods:

  • Fecal samples were collected from 19 males with ED and 15 healthy controls (aged 18-60).
  • Erectile function was assessed using the International Index of Erectile Function (IIEF-5).
  • Gut microbiota was characterized using macro-genomic sequencing on the NovaSeq PE 150 platform.

Main Results:

  • No significant differences in gut microbiota alpha diversity or overall composition (via PCA) were found between ED and control groups.
  • Specific bacterial species showed altered abundance: Ruminococcus gnavus, Thomasclavelia ramosa, Clostridium spp., and Eubacterium siraeum were more abundant in the ED group.
  • Bacteroides intestinalis abundance was decreased in the ED group, and pathways related to nucleotide and lipid metabolism were highly expressed.

Conclusions:

  • This pilot study identified a decrease in Bacteroides intestinalis and an increase in Ruminococcus gnavus in individuals with ED.
  • These microbial shifts may contribute to ED by promoting atherosclerosis and affecting branched-chain amino acid degradation.
  • Targeted gut microbiota regulation presents a potential future therapeutic strategy for improving outcomes in ED patients.