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Updated: Sep 18, 2025

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
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TRAPPC2l Participates in Male Germ Cell Development by Regulating Cell Division

Mengyue Wang1,2, Jiayi Li3,4, Bowen Liu3,4

  • 1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China.

Cell Proliferation
|June 20, 2025
PubMed
Summary

Transport Protein Particle complex subunit 2-like (TRAPPC2L) is crucial for male fertility. TRAPPC2L knockout mice showed abnormal germ cell development and complete infertility, highlighting its role in male germ cell maintenance.

Keywords:
Trappc2lGonocytemeiosisnon‐obstructive azoospermia (NOA)

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