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[Drug-induced systemic lupus erythematosus].

Sofie Døssing1, Tanja Todberg2, Søren Jacobsen1

  • 1Afdeling for Rygkirurgi, Led- og Bindevævssygdomme, Københavns Universitetshospital - Rigshospitalet.

Ugeskrift for Laeger
|June 20, 2025
PubMed
Summary

A 63-year-old female developed drug-induced systemic lupus erythematosus (SLE) due to multiple medications. Prompt diagnosis and treatment led to remission, emphasizing careful drug review in elderly patients.

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Area of Science:

  • Internal Medicine
  • Pharmacology
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) can be drug-induced.
  • Elderly patients often have complex medication regimens, complicating diagnosis.
  • Identifying specific drug triggers in polypharmacy is challenging.

Purpose of the Study:

  • To report a case of drug-induced SLE in an elderly patient.
  • To highlight the diagnostic challenges posed by polypharmacy.
  • To emphasize the importance of medication review for identifying drug triggers.

Main Methods:

  • Case report of a 63-year-old female patient.
  • Review of complex medication history including antihypertensives and proton pump-inhibitors.
  • Diagnostic workup including anti-histone antibodies.

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  • Treatment with immunosuppressants and drug discontinuation.

    • Main Results:

    • The patient was diagnosed with drug-induced SLE.
    • Anti-histone antibodies were positive, supporting the diagnosis.
    • Remission was achieved after treatment and discontinuation of suspected drugs.

    Conclusions:

    • Drug-induced SLE should be considered in elderly patients with polypharmacy.
    • Thorough medication review is crucial for identifying causative agents.
    • Early diagnosis and appropriate management lead to favorable outcomes.