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An Updated Review Deciphering the Inhibitory Potential of Erianin via Targeting Several Dysregulated Oncogenes in

Pratibha Pandey1,2, Seema Ramniwas3, Lalji Baldaniya4

  • 1Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.

Current Pharmaceutical Design
|June 20, 2025
PubMed

Insights

Erianin, a natural compound from Traditional Chinese Medicine, shows significant anticancer effects by targeting key cancer pathways and inducing apoptosis. Further research is needed to explore its potential in cancer therapy.

Area of Science:

  • Phytochemistry
  • Oncology
  • Molecular Biology

Background:

  • Edible plants contain anticarcinogenic compounds like phenolics and vitamins.
  • Current cancer therapies (surgery, chemotherapy, radiation) have limitations, including recurrence and side effects.
  • Novel chemotherapeutic agents are needed to improve outcomes and reduce metastasis.

Purpose of the Study:

  • To review the anticancer properties of Erianin (ER), a compound from Dendrobium chrysotoxum Lindl.
  • To elucidate the molecular mechanisms of Erianin's anticancer effects.
  • To highlight the potential of Erianin as a future cancer therapeutic agent.

Main Methods:

  • Literature review of studies on Erianin and cancer.
  • Analysis of Erianin's effects on cancer cell signaling pathways.
  • Examination of Erianin's impact on invasion, migration, and angiogenesis.

Main Results:

  • Erianin exhibits anticancer and antioxidative properties.
  • Erianin regulates multiple signaling pathways including PI3K/AKT, MEK, JNK, NRF2/PLOOH, JAK/STAT3, GSK3β, and NLRP3/ROS.
  • These pathways are crucial for inducing apoptosis and inhibiting cancer progression.

Conclusions:

  • Erianin demonstrates significant anticancer efficacy through various molecular mechanisms.
  • Targeting invasion, migration, and angiogenesis are key effects of Erianin.
  • Further investigation into Erianin's therapeutic potential is warranted.
Keywords:
Erianincancernatural productoncogenessignaling pathwaytraditional Chinese medicine.

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