Cefadroxil-Mupirocin Integrated Electrospun Nanofiber Films for Burn Wound Therapy

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Burn wound infections require effective antimicrobial strategies.
• Advanced drug delivery systems are crucial for managing complex wounds.
• Polyvinyl alcohol (PVA) and chitosan offer biocompatible matrices for drug encapsulation.

Purpose of the Study:

• To fabricate dual drug-loaded nanofibrous films using PVA and chitosan.
• To incorporate cefadroxil and mupirocin for comprehensive burn wound care.
• To evaluate the physicochemical, antibacterial, and in vivo wound healing properties of the nanofiber films.

Main Methods:

• Electrospinning of PVA/Chitosan nanofibers loaded with cefadroxil and mupirocin.
• Characterization using FTIR, SEM, TGA, and XRD.
• In vitro drug release kinetics and antibacterial assays against Staphylococcus aureus and Pseudomonas aeruginosa.
• In vivo assessment of wound healing efficacy in a rabbit full-thickness wound model.

Main Results:

• Uniform nanofibers with successful drug incorporation were fabricated.
• Drug release studies indicated an initial burst followed by sustained release.
• Significant antibacterial activity was observed, with notable inhibition zones.
• In vivo studies demonstrated accelerated wound contraction, achieving ~90% closure by day 17.

Conclusions:

• Cefadroxil-mupirocin nanofiber films exhibit potent antibacterial properties.
• These films significantly enhance the rate of wound healing.
• The developed nanofiber films show promising potential for advanced burn wound management.