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Updated: Sep 18, 2025
Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
Published on: February 9, 2021
Switching between type I/II photosensitization processes for of an unconventional dye as modulated by the tumor
Lei Hao1,2, Yumei Wang1, Shuang Zeng1,2
1State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China. lihd@dlut.edu.cn.
Abstract:
In this work, an unconventional Se-substituted hemicyanine dye (HCySe-O-NO2) decorated with a p-nitrophenyl moiety as a recognition site was investigated. Its type I/II photosensitization processes could be regulated by the tumor microenvironment, alleviating the oxygen dependence of conventional photodynamic therapy (PDT) for the treatment of solid tumors. Upon being exposed to 760-nm-wavelength laser irradiation, cancer cells treated with HCySe-O-NO2 exhibited the phenomenon of pyroptosis, resulting in an amplification of cellular immunogenic death (ICD), and hence demonstrating the potential value of this dye for photoimmunotherapy.
