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Adjuvant interventions for preventing kidney scarring in children with febrile urinary tract infection
Jitendra Meena1, Jogender Kumar2, Pankaj Hari3
1Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
The Cochrane Database of Systematic Reviews
|June 20, 2025
Insights
This review examines anti-inflammatory or antioxidative treatments to prevent kidney scarring in children with febrile urinary tract infections. It assesses the benefits and harms of these adjuvant interventions.
Area of Science:
- Pediatric nephrology
- Infectious diseases
- Pharmacology
Background:
- Febrile urinary tract infections (UTIs) are common in children.
- Kidney scarring is a serious complication of UTIs, potentially leading to long-term renal damage.
- Adjuvant therapies aim to mitigate inflammation and oxidative stress during UTIs.
Purpose of the Study:
- To evaluate the efficacy and safety of anti-inflammatory or antioxidative adjuvant interventions.
- To determine the impact of these interventions on preventing kidney scarring in children with febrile UTIs.
- To inform clinical practice regarding the management of pediatric febrile UTIs.
Main Methods:
- Systematic review of randomized controlled trials.
- Cochrane methodology for intervention reviews.
- Assessment of DMSA scan findings for kidney scarring.
- Evaluation of reported benefits and harms of adjuvant therapies.
Main Results:
- Data on the effectiveness of adjuvant anti-inflammatory or antioxidative interventions in preventing kidney scarring are currently limited.
- The safety profile and potential adverse effects of these adjuvant therapies require thorough investigation.
- Further research is needed to establish clear guidelines for their use.
Conclusions:
- The role of adjuvant anti-inflammatory or antioxidative interventions in preventing kidney scarring after febrile UTIs in children remains uncertain.
- Evidence regarding the benefits and harms of these treatments is insufficient to make definitive recommendations.
- High-quality research is necessary to guide clinical decision-making.
Abstract
Objectives:
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of adjuvant interventions (anti-inflammatory or antioxidative) in preventing kidney scarring (detected by DMSA scan) in children with febrile urinary tract infections.
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