Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

387
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
387
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

335
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
335
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
What are Second Messengers?01:12

What are Second Messengers?

85.0K
Because many receptor binding ligands are hydrophilic, they do not cross the cell membrane and thus their message must be relayed to a second messenger on the inside. There are several second messenger pathways, each with their own way of relaying information. G-protein coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol path is active when the receptor induces phospholipase C to hydrolyze the phospholipid,...
85.0K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

249
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
249
Amplifying Signals via Second Messengers01:15

Amplifying Signals via Second Messengers

7.3K
Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring bet-hedging in <i>Salmonella enterica</i> serovar Typhimurium with a dual reporter strain.

mSystems·2026
Same author

Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome.

Research square·2025
Same author

MERS-CoV and SARS-CoV-2 infection in diverse human lung organoid-derived cultures.

Journal of virology·2025
Same author

Targeting de novo purine biosynthesis for tuberculosis treatment.

Nature·2025
Same author

Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria.

eLife·2025
Same author

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome.

eLife·2023
Same journal

Antimicrobial Peptides and Biofilms: From Molecular Interactions to Therapeutic Control.

ACS infectious diseases·2026
Same journal

Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of <i>Mycobacterium tuberculosis</i> in Macrophages.

ACS infectious diseases·2026
Same journal

Correction to "<i>Treponema pallidum</i> Flagellin FlaB3 Activates Inflammation and Inhibits Autophagy in HMC3 Cells via the TLR4 Pathway".

ACS infectious diseases·2026
Same journal

Coumarin-Mediated Inhibition of Diadenylate Cyclase Correlates with Impaired Biofilm Formation in <i>Streptococcus mutans</i>.

ACS infectious diseases·2026
Same journal

Plasminogen Recruitment by <i>Staphylococcus aureus</i> SdrC Reveals a Tractable Antivirulence Target.

ACS infectious diseases·2026
Same journal

Suilysin of <i>Streptococcus suis</i> Serotype 2 Drives Astrocyte Pyroptosis via Activation of the ROS/NLRP3/Caspase-1/GSDMD Pathway.

ACS infectious diseases·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

580

Playing Telephone: How Secondary Messengers Influence Host-Pathogen Interactions in Tuberculosis.

Srivathsa Shankar Kurpad1,2, Neeraj Dhar1,3,4

  • 1Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada.

ACS Infectious Diseases
|June 20, 2025
PubMed
Summary
This summary is machine-generated.

Secondary messengers are crucial for cell communication. This review explores how Mycobacterium tuberculosis utilizes these molecules for pathogenesis and how targeting them could lead to new treatments.

Keywords:
cAMPhost−pathogenmycobacteriasecondary messengerssignal transductiontuberculosis

More Related Videos

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

597
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

1.9K

Related Experiment Videos

Last Updated: Sep 18, 2025

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

580
Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

597
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

1.9K

Area of Science:

  • Microbiology
  • Cellular Signaling
  • Molecular Biology

Background:

  • Secondary messengers are vital signaling molecules regulating cellular processes in prokaryotes and eukaryotes.
  • Mycobacterium tuberculosis possesses a complex system for synthesizing and degrading various secondary messengers.
  • The intracellular lifestyle of M. tuberculosis suggests potential crosstalk between host and bacterial signaling molecules.

Purpose of the Study:

  • To review the current understanding of secondary messenger signaling in Mycobacterium tuberculosis.
  • To explore the role of these messengers in M. tuberculosis pathogenesis and virulence.
  • To discuss the implications for developing novel vaccines and therapeutics.

Main Methods:

  • Literature review of existing research on secondary messengers in M. tuberculosis.
  • Analysis of genetic and molecular mechanisms involved in secondary messenger synthesis and degradation.
  • Examination of studies on host-pathogen interactions involving secondary messengers.

Main Results:

  • M. tuberculosis extensively utilizes secondary messengers for regulating its physiology.
  • Bacterial secondary messengers can modulate host immune responses, aiding pathogenesis.
  • Crosstalk between host and bacterial secondary messengers is a key aspect of M. tuberculosis infection.

Conclusions:

  • Secondary messenger signaling is a critical component of M. tuberculosis virulence.
  • Understanding these pathways offers opportunities for therapeutic intervention.
  • Targeting M. tuberculosis secondary messengers may lead to effective vaccines and treatments.