Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Antidepressant Drugs: Overview

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Treadmill exercise mediates the neuroprotective effect in post-stroke depression rats through the PGC-1α/FNDC5/irisin pathway.

Behavioural brain research·2026

Same author

Comparison of long-term and peri-operative complications between tunnelled and conventional peripherally inserted central catheters in patients with tumour: a systematic review and meta-analysis.

The Journal of hospital infection·2026

Same author

The impact of seasons on cognitive function, neuropsychiatric symptoms, and activities of daily living in patients with Alzheimer's disease.

Annals of medicine·2026

Same author

Irisin: Its significance in the diagnosis and treatment of post-stroke depression.

Journal of psychiatric research·2025

Same author

Interpretable Machine Learning for Predicting Neoadjuvant Chemotherapy Response in Breast Cancer Using the Baseline Clinical and Pathological Characteristics.

Cancer medicine·2025

Same author

Association Between Irisin Level and Cognitive Function: A Systematic Review and Meta-Analysis.

Brain and behavior·2025

Search research articles

Related Experiment Video

Updated: Sep 18, 2025

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Association between circulating irisin level and depression: a systematic review and meta-analysis.

Chengyan Han¹, Zining Zhou¹, Jianxing Zhao¹

¹School of Rehabilitation, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Annals of Medicine

|June 20, 2025

Summary

This meta-analysis found lower circulating irisin levels in patients with depression. Lower irisin levels correlate with more severe depressive symptoms, suggesting irisin

Keywords:

Depression irisin meta-analysis systematic review

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Related Experiment Videos

Last Updated: Sep 18, 2025

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Area of Science:

Endocrinology
Neuroscience
Psychiatry

Background:

Controversial findings exist regarding the association between irisin and depression.
Irisin, a myokine, plays roles in energy metabolism and has been implicated in various physiological processes.
Understanding irisin's role in depression is crucial for potential therapeutic targets.

Purpose of the Study:

To systematically review and meta-analyze studies investigating circulating irisin levels in depressive patients.
To determine the correlation between irisin levels and depression severity.

Main Methods:

Comprehensive literature search across PubMed, Embase, Web of Science, Cochrane Library, and Scopus up to July 18, 2024.
Inclusion of eight studies with 2044 participants (733 with depression, 1311 controls).
Data extraction and meta-analysis using standardized mean differences (SMD) and correlation coefficients (r).

Main Results:

Meta-analysis revealed significantly lower circulating irisin levels in depressive patients (SMD = 0.60, p = 0.02).
Subgroup analyses indicated decreased irisin in Asian patients, studies with >100 participants, serum samples, and studies including both genders.
A significant inverse correlation was found between irisin levels and depression scores (r = -0.47, p < 0.001).

Conclusions:

Circulating irisin levels are decreased in individuals with depression.
A negative correlation exists between irisin levels and depressive symptom severity.
Lower irisin may indicate more severe depressive symptoms, highlighting its potential as a biomarker.