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Updated: Sep 18, 2025

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Efficacy of oncolytic virus in the treatment of intermediate-to-advanced solid tumors: a systematic review and

Jin-Zhou Xu1, Jian-Xuan Sun1, Chen-Qian Liu1

  • 1Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of Virology
|June 20, 2025
PubMed

Insights

Oncolytic virus therapy shows significant promise for treating solid tumors, demonstrating a 29% overall response rate and improved survival outcomes compared to other treatments.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy

Background:

  • Solid tumors present significant treatment challenges.
  • Oncolytic virus therapy is an emerging cancer treatment modality.

Purpose of the Study:

  • To evaluate the efficacy of oncolytic virus therapy in patients with intermediate-to-advanced solid tumors.
  • To provide an updated and comprehensive analysis of existing research.

Main Methods:

  • Systematic literature search of PubMed, Cochrane Library, and Embase databases.
  • Meta-analysis of 87 studies (75 clinical trials, 12 retrospective studies) involving 5,385 patients.
  • Subgroup analyses to explore treatment variations.

Main Results:

  • Overall response rate (ORR) was 29%, with a complete response (CR) rate of 11% and partial response (PR) rate of 18%.
  • Durable response rate (DRR) was 39%.
  • Oncolytic virus therapy showed a favorable odds ratio (OR) of 1.62 for overall response and a hazard ratio (HR) of 0.86 for overall survival (OS) compared to alternatives.

Conclusions:

  • Oncolytic virus therapy is an effective treatment option for intermediate-to-advanced solid tumors.
  • This updated meta-analysis offers valuable insights for cancer researchers and clinicians.
  • The findings highlight the therapeutic potential of oncolytic viruses in solid tumor treatment.
Keywords:
intermediate-to-advanced solid tumormeta-analysisoncolytic virus

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