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Molindone and hepatotoxicity.

S C Bhatia, L E Banta, D W Ehrlich

    Drug Intelligence & Clinical Pharmacy
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Molindone treatment in an adolescent with schizophrenia led to drug-induced liver injury, indicated by flu-like symptoms and abnormal liver function tests. Discontinuation and re-challenge confirmed molindone-induced hepatic hypersensitivity.

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    Area of Science:

    • Pharmacology
    • Hepatology
    • Psychiatry

    Background:

    • Schizophrenia is a chronic mental disorder requiring long-term pharmacotherapy.
    • Molindone is an antipsychotic medication used for schizophrenia treatment.
    • Drug-induced liver injury (DILI) is a significant concern in pharmacotherapy.

    Observation:

    • An adolescent male diagnosed with chronic schizophrenic disorder, paranoid type, was initiated on molindone therapy.
    • The patient presented with flu-like symptoms and abnormal liver function tests during the early phase of molindone treatment.
    • Hepatic function normalized upon drug withdrawal and recurred upon reintroduction, suggesting a causal link.

    Findings:

    • The case demonstrates a potential association between molindone use and drug-induced liver injury.

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  • This represents a previously unreported instance of hepatic hypersensitivity to molindone.
  • Laboratory findings corroborated the clinical presentation of hepatotoxicity.

    • Implications:

    • Clinicians should consider molindone-induced hepatotoxicity in patients presenting with flu-like symptoms during early treatment.
    • Monitoring of liver function tests is recommended for patients on molindone, particularly those with prodromal flu-like symptoms.
    • This finding expands the known adverse effect profile of molindone and highlights the importance of vigilant drug monitoring in psychiatric pharmacotherapy.