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Updated: Sep 18, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Hypertrophic Cardiomyopathy and Pregnancy

Amha Weldehana1, Beeletsega Yeneneh2, Samrawit Zewde3

  • 1From the Department of Cardiology, Westchester Medical Center, Valhalla, NY.

Cardiology in Review
|June 20, 2025
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) in pregnancy is increasingly common. While often well-tolerated, this review examines diagnosis, risks, and management for expectant mothers with HCM.

Area of Science:

  • Cardiology
  • Genetics
  • Obstetrics

Background:

  • Hypertrophic cardiomyopathy (HCM) is an inherited condition affecting the heart muscle.
  • Increased screening leads to more women of reproductive age with HCM becoming pregnant.
  • Limited evidence exists on managing HCM during pregnancy.

Purpose of the Study:

  • To review the epidemiology of HCM in pregnancy.
  • To discuss clinical presentation and diagnostic challenges.
  • To outline management strategies for pregnant patients with HCM.

Main Methods:

  • Literature review of observational studies.
  • Analysis of clinical evidence on HCM and pregnancy.
  • Synthesis of data on diagnosis, risk stratification, and management.

Main Results:

  • HCM is generally well-tolerated during pregnancy for many women.
  • Normal pregnancy and delivery outcomes are frequently observed.
  • Potential complications necessitate pre-pregnancy intervention considerations.

Conclusions:

  • Pregnancy in women with HCM requires careful consideration of potential risks.
  • Early diagnosis and risk stratification are crucial.
  • Management strategies should be individualized, with potential need for advanced interventions.

Keywords:
hypertrophic cardiomyopathypregnancywomen

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